解剖学报

›› 2012, Vol. 43 ›› Issue (1): 139-144.doi: 10.3969/j.issn.0529-1356.2012.01.026

• 综述 • 上一篇    

转录因子环腺苷酸反应元件结合蛋白介导的细胞凋亡及其调控机制

李垒; 王萍*.   

  1. 宁波大学医学院人体解剖学与组织胚胎学系，浙江 宁波 315211
  • 收稿日期:2011-09-29 修回日期:2011-10-27 出版日期:2012-02-06
  • 通讯作者: 王萍

Cell apoptosis mediated by the transcription factor cAMP response element binding protein and its regulatory mechanism

  1. Department of Anatomy and Histology and Embryology，Medical School, Ningbo University, Zhejiang Ningbo 315211, China
  • Received:2011-09-29 Revised:2011-10-27 Online:2012-02-06
  • Contact: WANG Ping

关键词: 环腺苷酸反应元件结合蛋白, 信号通路

Abstract: Cell apoptosis is a complex and precise adjustment process, which involves numerous signal proteins. cAMP response element binding protein(CREB), a transcriptional regulation factor in eucaryotic cell, regulates the cell apoptosis through changing the intracellular signal transduction by its phosphorylation, which is a pop research in recent years. In this review, recent progress in studying the regulatory effects of transcription factor CREB on cell apoptosis is briefly summarized.

Key words: cAMP response element binding protein, Signal transduction

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